MERIDIA
MERIDIA (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity. Chemically, the active ingredient is a racemic mixture of the (+) and (-) enantiomers of cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H29Cl2NO. Its molecular weight is 334.33.
Is Meridia Safe?
Meridia has been associated with serious adverse health events in a number of obese patients. As a result, some countries have banned its use. That said, over 8.5 million patients worldwide have been prescribed the drug and thus the incidence of such side effects appears to be quite low. Over 100,000 American doctors have prescribed Meridia and it has been approved by the FDA since 1997. Its active ingredient, Sibutramine, has been clinically tested in over 100 trials involving more than 12,000 patients. It is one of the few drugs approved by the FDA for long-term treatment of obesity.
How Meridia Works
How Does Meridia Reduce Appetite? Does it Cause Weight Loss? Meridia® operates on two brain chemicals called Serotonin and Norepinephrine, which affect mood and appetite. According to clinical studies, Meridia® does help to reduce weight, although weight loss typically reduces after about 12 months. Meridia May Not Be Effective For Everyone Clinical studies of Meridia® and other appetite suppressants indicate that if a weight reduction of at least four pounds is not achieved within four weeks, then that particular medication is unlikely to lead to significant weight loss in the long run. What are the Health or Side Effects of Meridia? Patients using Meridia may experience restlessness, nervousness, anxiety, headache, dizziness, difficulty sleeping, dry mouth or constipation. More serious side effects can include: allergic reactions (examples include: difficulty breathing; closing of throat; swelling of lips, tongue, or face; hives); irregular heart-beat, increased heart-rate, or high blood pressure. For a full list of possible side effects, please consult your doctor.
Meridia Resources
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